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怎么翻译啊……

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发表于 2004-2-16 15:28:00 | 显示全部楼层 |阅读模式
TheBindingAbilityandInclusionComplexationBehaviorofCurcuminwithNaturalα ,β ,γ CyclodextrinsandOrganoselenium BridgedBis(β cyclodextrin)sQIAi di,LILiandLIUYu (DepartmentofChemistry,NankaiUniversity,Tianjin300071,China)Abstract:Aim Toinvestigatequantitativelythebindingabilityandinclusioncomplexationbehaviorofcurcuminwithnaturalα ,β ,γ cyclodextrins(1-3)andaseriesoforganoselenium bridgedbis(β cyclodextrin)swithsimplespacer(4-6).Methods ThespectrophotometrictitrationshavebeenperformedinKCl HClbuffersolution(pH=2.0)at25℃tocalculatethecomplexstabilityconstants(Ks)andGibbsfreeenergychanges(ΔG°)forthestoichiometric1∶1inclusioncomplexationof1-6withcurcumin.Results Thebindingabilityofβ cyclodextrinforinclusioncomplexationwithguestcurcuminishigherthanthatofα andγ cyclodextrins.Ascomparedwithparentβ cyclodextrin,theorganoseleniumbridgedbis(β cyclodextrin)stetheredbysomefunctionalgroupscanfurtherenhancetheoriginalmolecularbindingabilitythroughcooperativebindingofonecurcuminmoleculeinthecloselylocatedtwocyclodextrincavities,showingtheenhancedbindingabilitiesofparentβ cyclodextrinbyafactor2.8-17.1.Conclusion Size shapefitandhydrophobicinteractionbetweenhostcyclodextrinsandguestcurcuminmoleculearetheimportantfactorsaffectingthebindingabilityandinclusioncomplex ationbehaviorofthesecyclodextrins1-6.Keywords:curcumin;modifiedcyclodextrin;molecularrecognition;inclusioncomplexationCLCnumber:R913;O648.2   Documentcode:A   ArticleID:1003-1057(2003)01-015-06IntroductionCurcumin,theextractionofanaturalproductcurcu ma,hasbactericidalactionandmayminimizeoxidativedamage.Itsantioxidantmechanism[1]andpharmacologicaleffectsforanti cancer[2]arebeingresearchedinrecentyears.Curcuminispracticallyinsolubleinaqueousmedia,butdissolvedinorganicsolvents.Sincetheuseoforganicsolventsincertaincaseneedstobeavoided,theincreaseofitssolubilityinaqueoussolutionmaybeimportant.Cyclicoligosaccharides,composedofsixtoeightlinkedD glucopyranoseunitsformingtruncatedconicalstructures,arenamedasα ,β ,andγ cyclodextrinsre spectively.Possessinghydrophobiccavitiesofdifferentsize,naturalandmodifiedcyclodextrinscanbindvariousmoleculesofrespectivesizeandshapetoforminclusionReceiveddate:December20,2002Biography:QIAi di,OnleavefromTianjinCollegeofTraditionalChi neseMedicine Correspondingauthor:Tel+86 022 23503625E <A href="mailto:mailyuliu@public.tpt.tj.cncomplexesinaqueoussolution,whichwasuseddistantlyinscienceandtechnologyfield[3" target="_blank" >mailyuliu@public.tpt.tj.cncomplexesinaqueoussolution,whichwasuseddistantlyinscienceandtechnologyfield[3</A> 4]especiallyformolecularrecognitionwithaseriesofguestmolecules,suchasdye s[5 7],alcohols[8],andaminoacid[9 11]etc,andwhichcanalsoenablecyclodextrinstobesuccessfullyusedasdrugcarriers[12]forincreasingtheaqueoussolubilityoforganicmolecules,suchascurcumin.Ontheotherhand,thelowaqueoussolubilityofnaturalcyclodextrins,particularlythatofβ cyclodextrin,restrictstheiruseofdrugcarriers.Therefore,aseriesofcyclodextrinderivativesofgoodaqueoussolubilityhavebeendesignedandsynthesizedinordertoresolvethisproblem.Recently,thestabilizationandsolubilizationoftheinclusioncomplexformedbythecurcuminwithcyclodextrinshavebeenstudiedanddis cussedbySzenteetal[13],givingthesignificantresults.Unfortunately,thestudiesaboutbindingabilityandinclu sioncomplexationbehaviorsofcurcuminmoleculewithcy clodextrinsandtheirderivativesarestillrare.Wehavere centlyshownthattheorganoseleniumbridgedbis(β cyclo dextrin)spossessingtheexcellentaqueoussolubilityandthelowtoxicityformmorestablecomplexeswithdyemole culesthannativeβ cyclodextrin[14 16].51JournalofChinesePharmaceuticalSciences2003,12(1)
发表于 2004-2-17 09:23:00 | 显示全部楼层
杀了我吧
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发表于 2004-2-21 11:12:00 | 显示全部楼层
Something wrong with your mind?


Bullshit!!

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发表于 2004-2-21 21:27:00 | 显示全部楼层
kill me!
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发表于 2004-5-17 13:53:00 | 显示全部楼层
简单,动词用“搞”来代替,汉翻英动词用“get”
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发表于 2004-7-10 21:32:00 | 显示全部楼层
[em5]楼主同志,为了体谅咱们的视觉,拜托能不能单词之间空格啊~~!!!!
或是换一种比较容易看得字体阿~~~
我怎么越看越像乱码~~[em11]
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发表于 2004-7-16 11:25:00 | 显示全部楼层
晕,杀了我吧

能不能加上空格啊,有不费你地方

头都大了
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发表于 2004-9-21 14:51:00 | 显示全部楼层
oh,my god!
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发表于 2005-2-3 09:53:00 | 显示全部楼层
老大,你搞笑啊 这都看不懂啊 这根本翻译不出来啊

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发表于 2005-2-3 10:46:00 | 显示全部楼层
The  Binding  Ability  and  Inclusion  Complexation  Behavior  of  Curcumin  with  Naturalα ,β ,γ .
如上断句后即可翻译~~~~
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